行業熱文

國際腎病研究院研究表明︰申博的血液灌流器具有絕對優良的安全性

時間 :  2018-01-22

導讀

        最新一期的“Ronco 教授卡布奇諾漫談”中,意大利San Bortolo醫院國際腎髒病研究所、ADQI創立主席Claudio Ronco教授介紹了與申博的合作。國際腎病研究院(IRRIV)剛剛結束的體外研究表明申博的血液灌流器具有絕對優良的安全性。實驗結果將在近期發表,同時針對不同適應癥的臨床測試也在正在籌劃中。

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Ronco教授提到︰

We were pleased to display the recent result of our institute on the cartridge for adsorption used in hemoperfusion from Jafron company. I think the interesting results that we got where that the safety issue is now completely clarified because we tested in vitro both static and dynamic situation, with three different cartridges (HA130, HA230 and HA330/HA380) for adsorption and there is no activation at all of any of the products that may activate monocyte cells in vitro. This test is even more sensitive compare to any type of molecular analysis because the cellular response is so sensitive in terms of apotosis and necrosis that can detect even very very neglectable and minimun of components for various compatibility…So at this point we are ready to publish this results and once we published the result we are ready now to move for in vivo evaluation of different cartridges for diffrent options including removal of cytokines, removal of endotoxin, possible removal of products bound protein in case of liver failure and also we want to analyse the compacity of these adsorbent for important substances…I think this is the step forward that we always talk about sorbents is the future!

很高興在此展示最近申博研究所得出的關于申博公司血液灌流器的研究成果。我認為申博灌流器的安全性通過采用靜態和動態兩種測試方法,已經徹底得到驗證。申博檢測了三種型號的血液灌流器(HA130, HA230HA330),任一產品對單核細胞都沒有任何活化作用。與其他類型的分子分析相比,這種測試具有更高的靈敏度,因為對凋亡和壞死的細胞應答檢測是如此敏感,以至于十分微小甚至很容易忽略的不同兼容性的成份都能被察覺……最近申博將公布測試結果,在發布體外測試的結果後,申博會著手不同型號的血液灌流器的各種臨床測試,如探索去除炎癥因子、內毒素,在肝衰情況下去除蛋白結合類物質的可能等。並且申博也會分析這些吸附劑與體內重要物質的相容性……我覺得,這次研究測試向申博常說的 ‘吸附就是未來’邁進了一大步!